Pharmacokinetics and pharmacodynamics in the elderly

Pharmacokinetics and pharmacodynamics in the elderly.

drug–drug interactions and adverse drug effects compared with younger patients makes use of pharmacologic agents in the elderly much more ­difficult.­ Usually,­ elderly­ is­ defined­ by­ a­ chronological age of 65 years or older.­ One­ should­ be­ aware­ of­ the­ great­ variability­ in­ pharmacokinetics and pharmacodynamics in the­ elderly.­ The­ variability­ seen­ in­ younger persons is much i...

Pharmacodynamics and pharmacokinetics in the elderly.

The paper deals with changes in pharmacodynamics (the study of what the drug does to the body) and pharmacokinetics (the study of what the body does to the drug) in the elderly. Elderly population takes 25–30 per cent of drugs taken by total population. In the elderly pharmacodynamics and pharmacokinetics are altered. According to pharmacokinetics, gastric juice pH is elevated which influences ...

Pharmacokinetics/ Pharmacodynamics

Topiramate: pharmacokinetics and pharmacodynamics.

Topiramate is a structurally novel anti-epileptic drug with at least 3 postulated mechanisms of action including: 1) potentiation of GABA responses, 2) impairment of AMPA/kainate glutamate receptors and 3) suppression of high frequency action potential firing. It has a favourable pharmacokinetic profile with rapid absorption, good bio-availability, linear pharmacokinetics, relatively long half-...

Macrolides: pharmacokinetics and pharmacodynamics.

Three pharmacokinetic/pharmacodynamic parameters--(i) the peak concentration to the minimum inhibitory concentration ratio (C(max)/MIC); (ii) the area under the concentration-time curve to MIC ratio (AUC(24h)/MIC); and (iii) the time the concentration exceeds the MIC (T>MIC)--are important predictors of the clinical efficacy of antibiotics. For antibiotics with pronounced concentration-dependen...